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<meta content="Hasbroucq, T." name="eprints.creators_name" />
<meta content="Tandonnet, Christophe" name="eprints.creators_name" />
<meta content="Micallef-Roll, J." name="eprints.creators_name" />
<meta content="Blin, O." name="eprints.creators_name" />
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<meta content="ct6@postoffice.sandybay.utas.edu.au" name="eprints.creators_id" />
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<meta content="2007-10-09 22:15:46" name="eprints.datestamp" />
<meta content="2008-01-08 15:30:00" name="eprints.lastmod" />
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<meta content="An electromyographic analysis of the effect of levodopa
on the response time of healthy subjects" name="eprints.title" />
<meta content="pub" name="eprints.ispublished" />
<meta content="210000" name="eprints.subjects" />
<meta content="440100" name="eprints.subjects" />
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<meta content="Levodopa · Healthy subjects · Reaction time ·
Motor time" name="eprints.keywords" />
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<meta content="Abstract Rationale: Recently, we have shown that oral
absorption of levodopa shortens reaction time (RT),
measured as the interval between the response signal
and the onset of voluntary electromyographic (EMG)
activity. The motor time (MT) interval that elapses from
the EMG activity to the mechanical response was not
analysed. Objective: The purpose of the present study was
to analyse the effect of the dose of levodopa administrated
in our previous study on the MT. Eight healthy adults
(aged 21–28, mean=25), performed a two-choice visual
RT task after oral absorption of a single dose of levodopa
(200 mg) or a placebo (randomized, double-blind, crossover
design). Results: Like RT, MT was shorter under
levodopa than under placebo. Statistical analyses demonstrated
that this effect was present for all deciles of the RT
and MT distributions. Conclusion: Levodopa shortens not
only RT but also MT, which points at the implication of
the dopaminergic system in both premotor and motor
processes." name="eprints.abstract" />
<meta content="2003" name="eprints.date" />
<meta content="published" name="eprints.date_type" />
<meta content="Psychopharmacology" name="eprints.publication" />
<meta content="165" name="eprints.volume" />
<meta content="313-316" name="eprints.pagerange" />
<meta content="10.1007/s00213-002-1304-y" name="eprints.id_number" />
<meta content="TRUE" name="eprints.refereed" />
<meta content="0033-3158" name="eprints.issn" />
<meta content="http://dx.doi.org/10.1007/s00213-002-1304-y" name="eprints.official_url" />
<meta content="References
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Fig. 1 Cumulative density functions for the three chronometric
variables of the study. MT motor time, RT reaction time
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Rihet P, Possama C-A, Micaleff-Roll J, Blin O, Hasbroucq T
(2002) Dopamine and human information processing: a reaction
time analysis of the effect of levodopa in healthy subjects.
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Vaidya CJ, Austin G, Kirkorian G, Ridlehuber W, Desmond JE,
Glover G, Gabrieli JDE (1998) Selective effects of methylphenidate
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316" name="eprints.referencetext" />
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<meta content="Tandonnet, Christophe" name="DC.creator" />
<meta content="Micallef-Roll, J." name="DC.creator" />
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<meta content="Abstract Rationale: Recently, we have shown that oral
absorption of levodopa shortens reaction time (RT),
measured as the interval between the response signal
and the onset of voluntary electromyographic (EMG)
activity. The motor time (MT) interval that elapses from
the EMG activity to the mechanical response was not
analysed. Objective: The purpose of the present study was
to analyse the effect of the dose of levodopa administrated
in our previous study on the MT. Eight healthy adults
(aged 21–28, mean=25), performed a two-choice visual
RT task after oral absorption of a single dose of levodopa
(200 mg) or a placebo (randomized, double-blind, crossover
design). Results: Like RT, MT was shorter under
levodopa than under placebo. Statistical analyses demonstrated
that this effect was present for all deciles of the RT
and MT distributions. Conclusion: Levodopa shortens not
only RT but also MT, which points at the implication of
the dopaminergic system in both premotor and motor
processes." name="DC.description" />
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<h1 class="ep_tm_pagetitle">An electromyographic analysis of the effect of levodopa on the response time of healthy subjects</h1>
<p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Hasbroucq, T.</span> and <span class="person_name">Tandonnet, Christophe</span> and <span class="person_name">Micallef-Roll, J.</span> and <span class="person_name">Blin, O.</span> (2003) <xhtml:em>An electromyographic analysis of the effect of levodopa on the response time of healthy subjects.</xhtml:em> Psychopharmacology, 165 . pp. 313-316. ISSN 0033-3158</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a href="http://eprints.utas.edu.au/2151/1/Hasbroucq%2CTandonnet%2CMicaleff-Roll%2CB.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a></td><td valign="top"><a href="http://eprints.utas.edu.au/2151/1/Hasbroucq%2CTandonnet%2CMicaleff-Roll%2CB.pdf"><span class="ep_document_citation">PDF</span></a> - Full text restricted - Requires a PDF viewer<br />142Kb</td><td><form method="get" accept-charset="utf-8" action="http://eprints.utas.edu.au/cgi/request_doc"><input accept-charset="utf-8" value="2694" name="docid" type="hidden" /><div class=""><input value="Request a copy" name="_action_null" class="ep_form_action_button" onclick="return EPJS_button_pushed( '_action_null' )" type="submit" /> </div></form></td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://dx.doi.org/10.1007/s00213-002-1304-y">http://dx.doi.org/10.1007/s00213-002-1304-y</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">Abstract Rationale: Recently, we have shown that oral
absorption of levodopa shortens reaction time (RT),
measured as the interval between the response signal
and the onset of voluntary electromyographic (EMG)
activity. The motor time (MT) interval that elapses from
the EMG activity to the mechanical response was not
analysed. Objective: The purpose of the present study was
to analyse the effect of the dose of levodopa administrated
in our previous study on the MT. Eight healthy adults
(aged 21–28, mean=25), performed a two-choice visual
RT task after oral absorption of a single dose of levodopa
(200 mg) or a placebo (randomized, double-blind, crossover
design). Results: Like RT, MT was shorter under
levodopa than under placebo. Statistical analyses demonstrated
that this effect was present for all deciles of the RT
and MT distributions. Conclusion: Levodopa shortens not
only RT but also MT, which points at the implication of
the dopaminergic system in both premotor and motor
processes.</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Additional Information:</th><td valign="top" class="ep_row">The original publication is available at www.springerlink.com
</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">Levodopa · Healthy subjects · Reaction time ·
Motor time</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/210000.html">210000 Science - General</a><br /><a href="http://eprints.utas.edu.au/view/subjects/440100.html">440000 Philosophy and Religion > 440100 Philosophy</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">2151</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">Scholarly Publications Librarian</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">10 Oct 2007 09:15</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=2151;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&eprintid=2151">item control page</a></p>
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